10 Easy Flight + Train Combo Trips in Europe You Can Do in One Week

If you’re planning a European adventure in 2025 and want to experience more than one destination without the stress of long travel days, flight + train combo trips are your answer. These carefully paired city combos are perfect for one-week getaways, combining the speed and accessibility of budget flights with the comfort and charm of scenic European train rides.

Each pair is not only logistically smooth — with direct connections and no night trains — but also ideal for mixing culture, food, landscapes, and affordability. Plus, using Travelupo, you can easily compare flights, find boutique stays, and plan your itinerary all in one place.

Here are 10 of the best combos to consider for your next week-long European trip that have been hand picked via Travelupo for your desire!

1. Vienna, Austria → Prague, Czech Republic

Fly into: Vienna International Airport
Train to Prague: ~4 hours, direct
Why it works: Vienna enchants with classical music, imperial palaces, and stately cafés, while Prague dazzles with Gothic spires, fairytale bridges, and Bohemian flair. Both cities offer rich cultural heritage and delicious local cuisines at affordable prices.
Top Tips: Visit Vienna’s Schönbrunn Palace, enjoy a slice of Sachertorte, then hop on a comfortable Railjet to Prague. There, explore Charles Bridge, Old Town Square, and Prague Castle.
Travelupo Tip: Spend 3 nights in Vienna, then take a morning train to Prague for 3 more. Book hotels near train stations for easy transitions.

2. Rome, Italy → Florence, Italy

Fly into: Rome Fiumicino (FCO)
Train to Florence: 1.5 hours, high-speed
Why it works: Rome is buzzing with ancient history and modern Italian life, while Florence is quieter and drenched in Renaissance art and architecture.
Top Tips: Tour the Colosseum and Vatican Museums in Rome before heading to Florence’s Uffizi Gallery and Ponte Vecchio. Don’t miss a Tuscan sunset with a glass of Chianti.
Travelupo Tip: Combine cheap Rome flights with centrally located Florence B&Bs for a well-balanced week.

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3. Lisbon, Portugal → Porto, Portugal

Fly into: Lisbon Humberto Delgado Airport
Train to Porto: 3 hours, direct Intercidades
Why it works: Lisbon charms with tiled facades and Fado music, while Porto offers scenic riverfronts and iconic port wine cellars.
Top Tips: Ride Tram 28 in Lisbon, dine on bacalhau, then ride the train north along the Atlantic to Porto. In Porto, cruise the Douro River and explore the Ribeira neighborhood.
Travelupo Tip: Use Travelupo to find off-season deals. Try staying in a Lisbon guesthouse and a wine lodge in Porto.

4. Nice, France → Cinque Terre, Italy

Fly into: Nice Côte d’Azur Airport
Train to La Spezia (Cinque Terre): ~5 hours, with coastal views
Why it works: Nice blends French Riviera glam with beachside relaxation. Cinque Terre offers colorful cliffside villages and slow-paced coastal living.
Top Tips: Spend time at the Promenade des Anglais in Nice, then take the coastal train to La Spezia and hop between the five towns. Perfect for hiking and seafood lovers.
Travelupo Tip: Split your stay with 4 nights in Nice and 3 in Monterosso al Mare. Book scenic-view stays via Travelupo.

5. Amsterdam, Netherlands → Bruges, Belgium

Fly into: Amsterdam Schiphol Airport
Train to Bruges: ~3 hours, via Brussels
Why it works: Amsterdam is modern, artistic, and vibrant. Bruges is quiet, romantic, and steeped in medieval charm.
Top Tips: In Amsterdam, visit the Van Gogh Museum and Anne Frank House. Then ride south to Bruges to explore canals, cobblestone streets, and chocolatiers.
Travelupo Tip: Use Travelupo to compare hotels in old-town Bruges and Jordaan, Amsterdam.

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6. Barcelona, Spain → Valencia, Spain

Fly into: Barcelona El Prat Airport
Train to Valencia: ~3 hours, direct Euromed service
Why it works: Barcelona boasts Gaudí masterpieces, buzzing nightlife, and Mediterranean flavor. Valencia offers sandy beaches, modern architecture, and excellent paella.
Top Tips: After admiring La Sagrada Familia, take the train to Valencia’s City of Arts and Sciences and try horchata at a local café.
Travelupo Tip: Book early for high-speed train discounts and consider boutique hotels with rooftop pools.

7. Berlin, Germany → Dresden, Germany

Fly into: Berlin Brandenburg Airport
Train to Dresden: ~2 hours
Why it works: Berlin offers edgy art, Cold War history, and multicultural cuisine. Dresden dazzles with baroque landmarks and museums.
Top Tips: Visit the Berlin Wall and Museum Island, then unwind in Dresden’s Old Town. The Frauenkirche and Zwinger Palace are must-sees.
Travelupo Tip: Travelupo helps compare budget flights into Berlin and hotel deals in Dresden’s Altstadt.

8. Copenhagen, Denmark → Malmö, Sweden

Fly into: Copenhagen Airport (CPH)
Train to Malmö: 40 minutes over the Øresund Bridge
Why it works: It’s the easiest two-country trip in Europe. Copenhagen is stylish and design-forward. Malmö is hip and laid-back with Swedish charm.
Top Tips: Spend a few days exploring Copenhagen’s Nyhavn and Tivoli Gardens. Then ride the train to Malmö for seaside biking, art museums, and fika.
Travelupo Tip: Book Copenhagen flights and stay in Malmö for lower hotel rates while enjoying day trips both ways.

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9. Athens, Greece → Thessaloniki, Greece

Fly into: Athens International Airport
Train to Thessaloniki: 4–5 hours, with coastal and inland views
Why it works: Athens serves ancient history, while Thessaloniki is a cultural hub with a youthful twist.
Top Tips: Visit the Acropolis, dine in Plaka, then head north for waterfront promenades and Byzantine history in Thessaloniki.
Travelupo Tip: Pair archaeological adventures with seaside dining. Look for fall shoulder-season rates on Travelupo.

10. Zurich, Switzerland → Lucerne, Switzerland

Fly into: Zurich Airport
Train to Lucerne: Just 1 hour, direct
Why it works: Zurich is sleek, modern, and financial; Lucerne is cozy, scenic, and rooted in tradition.
Top Tips: Walk Zurich’s Bahnhofstrasse, then take the train to Lucerne to ride a paddle steamer on Lake Lucerne and catch views from Mount Pilatus.
Travelupo Tip: Book your Zurich hotel near the old town, and enjoy lakefront stays in Lucerne with mountain views.

Popular Add-Ons to Customize Your Trip

Want a little more flexibility? Add in a half-day stopover between your two main destinations. For example:

Between Amsterdam and Bruges: spend a few hours in Brussels for waffles and Grand Place photos.
Between Nice and Cinque Terre: stop in Genoa for fresh pesto.
Between Berlin and Dresden: visit Potsdam’s palaces.

Small detours create big memories!

Why Combo Trips Are the Smart Way to Travel Europe

Flight + train itineraries let you maximize your one-week escape by cutting out transit chaos. Instead of trying to squeeze in 4–5 cities and rushing, focus on two well-matched spots and enjoy them at your own pace. You’ll save money on shorter rail legs, avoid multiple flights, and get more immersive experiences.

These types of trips are ideal for solo travelers, couples, and digital nomads alike — offering balance between movement and relaxation.

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Packing & Planning Tips

Pack light: carry-ons only make it easier to move between cities
Buy train tickets in advance to save on fares and secure your seats
Stay near train stations for quick access
Use Travelupo to compare dates for lowest airfare and lodging rates

Book Your Perfect Europe Combo with Travelupo

Planning your perfect flight + train trip is easier than ever. With Travelupo, you can search cheap inbound flights, compare rail-friendly hotel stays, and plan your transitions all in one place.

From dynamic cities to scenic towns, Travelupo helps you get the best out of Europe — one smooth connection at a time.

👉 Start building your Europe combo trip at Travelupo.com and turn one week into a real adventure.